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THE QUESTION LIBRARY LIFE IN THE UNIVERSE

How can humans and chimpanzees share so much DNA and still be so different?

THE SHORT ANSWER

Similar genes can contribute differently when their activity changes in amount, location or timing. DNA similarity alone does not describe how those genes are used.

WHERE THE EVIDENCE STANDS

How sure are we?

  • One similarity percentage includes every kind of DNA difference.
  • Gene regulation controls the timing, location and amount of gene activity.
  • Humans descended from modern chimpanzees.
What the labels mean

Humans and chimpanzees inherited much of their DNA from a shared ancestor. Similar DNA can produce different bodies when some protein instructions and patterns of gene activity differ. A similarity percentage also depends on what was compared.

THE LONG ANSWER

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Sources & further reading

(3)
  1. Genetics ↗Smithsonian Human Origins
  2. Initial sequence of the chimpanzee genome and comparison with the human genome ↗Chimpanzee Sequencing and Analysis Consortium, Nature 437:69–87 (2005)
  3. Gene Regulation ↗National Human Genome Research Institute

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