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THE QUESTION LIBRARY LIFE IN THE UNIVERSE

What decides which genes win in evolution: fitness, luck or timing?

THE SHORT ANSWER

Selection favors inherited reproductive advantages; chance, timing, competition and the environment can change which variants spread.

WHERE THE EVIDENCE STANDS

How sure are we?

  • Fitness concerns relative reproductive contribution.
  • The first beneficial mutation always wins.
  • A mutation’s benefit can depend on the environment.
What the labels mean

Fitness, luck and timing can all matter. Which matters most depends on the population, its surroundings and which competing variants are available.

THE LONG ANSWER

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Sources & further reading

(5)
  1. Science and the Endangered Species Act ↗National Research Council (1995)Box 7-1, page 127.
  2. Genetic Drift ↗NHGRIDefinition; narration.
  3. Beneficial Mutation–Selection Balance and the Effect of Linkage on Positive Selection ↗Desai and Fisher, Genetics 176:1759–1798 (2007)Figure 1; pages 1762, 1780.
  4. The Speed of Evolution and Maintenance of Variation in Asexual Populations ↗Desai, Fisher and Murray, Current Biology 17:385–394 (2007)Summary; Results.
  5. High-Throughput Identification of Adaptive Mutations in Experimentally Evolved Yeast Populations ↗Payen and colleagues, PLOS Genetics 12:e1006339 (2016)Results; Figure 2.

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