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THE QUESTION LIBRARY LIFE IN THE UNIVERSE

How can identical twins with the same DNA turn out so different?

THE SHORT ANSWER

Shared DNA does not guarantee identical lives. Conditions before birth, later environments and differences in gene activity can contribute; epigenetics is one part of that picture.

WHERE THE EVIDENCE STANDS

How sure are we?

  • Epigenetic marks change DNA’s letter sequence.
  • Twin differences must come entirely from environment.
  • A family resemblance proves inherited memories or experiences.
What the labels mean

Identical twins develop from one fertilized egg and begin with almost the same DNA. Yet their conditions before birth, later environments and gene activity can differ. Shared DNA does not guarantee identical lives.

THE LONG ANSWER

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Sources & further reading

(4)
  1. Epigenomics Fact Sheet ↗National Human Genome Research Institute
  2. Monozygous but not identical ↗deCODE genetics (2021)Investigator research report.
  3. Epigenetic differences arise during the lifetime of monozygotic twins ↗Fraga and colleagues, PNAS 102:10604–10609 (2005)
  4. A critical view on transgenerational epigenetic inheritance in humans ↗Horsthemke, Nature Communications 9:2973 (2018)Commentary; public university copy.

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