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How do bacteria become resistant to antibiotics?

THE SHORT ANSWER

Bacteria gain defenses through DNA changes or shared genes. Antibiotics can favor resistant survivors. Evolution has patterns, but its exact next change is uncertain.

WHERE THE EVIDENCE STANDS

How sure are we?

  • Resistance genes can spread between bacteria.
  • Laboratory populations can follow similar resistance routes.
  • A forecast can guarantee the next new mutation.
What the labels mean

Bacteria can resist an antibiotic through changes in their DNA or by acquiring resistance genes from other bacteria. The bacteria become resistant; the person’s body does not. Antibiotics can then favor resistant survivors.

THE LONG ANSWER

THE LONG ANSWER · ABOUT 2 MINUTES

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Sources & further reading

(5)
  1. About Antimicrobial Resistance ↗CDC (2025)Resistance mechanisms.
  2. How Antibiotic Resistance Moves Directly Germ to Germ ↗CDCPage 1.
  3. Evolutionary paths to antibiotic resistance under dynamically sustained drug selection ↗Toprak and colleagues, Nature Genetics 44:101–105 (2012)Pages 101–104.
  4. A predictive fitness model for influenza ↗Łuksza and Lässig, Nature 507:57–61 (2014)Abstract.
  5. Recommended composition of influenza virus vaccines for use in the 2027 southern hemisphere influenza season ↗WHO (September 25, 2026)Page 3.

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